San Francisco is the 12th largest financial center in the world. Downtown, there are a lot of pies for vampires to stick their fingers into.
Until the return of the Camarilla, it was Giovanni territory, but it is now claimed by the Ventrue. Cedric Antonio still ostensibly claims a large section, though he is no longer Prince and does not have a large enough following to vie for the position – yet. Leslie Whitaker and Sarah Anne Wilder each have a small stake in this part of the city, and presulably the Giovanni still have a presence there, though they are very quiet about it.